Silicon Valley Area Chapter

(SCV, SF, OEB)

Design of Experiments (DOE), Statistical Process Control (SPC), and Sampling: Panel Discussion

Panelists: Qamar Asgar, John Zorich, and Patrick Giuliano
Registration not required; check in on Zoom at 6:00 PM PST.
Meeting Date: Wednesday, November 11, 2020
Time: Checkin via Zoom at 6:00 PM; Panel at 6:10 PM (PDT)
Cost: none
Zoom link: zoom.us/j/97466551724?pwd=OW9pcVh6c29oVFMwWGxxeUNZdy9rZz09
Meeting ID: 974 6655 1724; Meeting password: 635184
Summary: Here’s a question based upon a recent COVID-19 study. There were trials of a special medicine recently in Spain. 76 patients with COVID-19 symptoms were admitted to a hospital. They were all given a standard course of medicines, upon admission, but the treatment course was randomized and split into two groups, where the medical staff and patients didn’t know who was in each group. In other words, it was a randomized, double-blind study, the gold standard for medical trials, though the group was small, just 76. 50 were given the standard medicines plus the special extra medicine. 26 were given only the standard course of medicines
In the first group, 1 of the patients was admitted to intensive care and nobody died. In the second group, 13 of the 26 later required admission to intensive care and 2 of them died.
One would conclude that the first group fared much better than the second. Likely it was statistically significant — say, relative to admission to intensive care.
How would you approach this problem, say with JMP or MiniTab? With which p level would you assign the significance of the addition of just one medication to the treatment plan? Recall (p=1-confidence level) that a sample subpopulation is substantially different from the null hypothesis, the 26 of the trial in Spain. Show your work or show a computer screen to demonstrate your calculation.
For extra credit, what might that extra medication have been? Hint: it was among about 6 medications President Trump took before he climbed aboard Marine One for his trip to Walter Reed Hospital late Saturday, October 3. No, it wasn’t bleach. This medication has been shown to provide activation to killer T-cells in your innate immune system, though the president likely did not have enough in his body from the handful of pills he took before his trip to the hospital. I will reveal more details on Nov.11. It may change the way you protect yourself from the pandemic. It has impacted me, at least so far, though I do mask and refuse to attend large political rallies.
Organized by the ASQ Silicon Valley Section’s Statistics & Reliability Discussion Group