CMOS biochips: The good, the bad, and the hype


Speaker: Arjang Hassibi, InSilixa

Time: May 19th (Thursday) evening 6.30 pm-8.30pm.


In the past two decades, there has been numerous attempts to take advantage of semiconductor solutions, broadly defined, to create high-performance biosensors and bio-molecular detection devices. The goal has always been to create molecular diagnostics technologies that offer the cost efficiency, miniaturization capabilities, and manufacturing robustness of consumer electronics devices. The outcome so far, has not been very exhilarating and unfortunately there has been few impactful products based on such efforts.

In this talk, we will discuss the use of CMOS processes and IC’s for biotechnology in the form of integrated biochips. The focus will be not only the design, manufacturing, and the packaging of biochips, but on the biochemistry and applications requirements. We will also discuss in detail a few implemented biochips that InSilixa is currently developing for commercialization in the nucleic acid (DNA/RNA) testing applications.


Arjang Hassibi – (M’99–SM’12) is the CEO of InSilixa, a startup company in Sunnyvale, CA which is developing the first-generation of fully-integrated CMOS biochips for DNA testing.

Arjang area of expertise is the intersection of electrical engineering and biotechnology, specifically the use of high-performance analog and mixed-signal IC design for biosensing in applications such as DNA sequencing and molecular diagnostics. Prior to starting InSilixa Inc., he was a faculty member at the Electrical and Computer Engineering Department and the Institute for Cellular and Molecular Biology of The University of Texas at Austin. He also has held various R&D positions in both industry and academia including Stanford Genome Technology Center, IBM Research at Yorktown, and Xagros Genomics, a startup company which he co-founded in 2001. Most recently, he was the Healthcare Thrust Lead at the Silicon Research Corporation (SRC).

Arjang received his B.Sc. with the highest honors from the University of Tehran, Iran, and both his M.Sc. and Ph.D. degrees from Stanford University, all in electrical engineering. He attended Caltech for his postdoctoral training. He has more than 100 technical publications and patents, almost all in the multidisciplinary area of biosensors and bioelectronics.


Santa Clara Valley Chapter of the Solid State Circuits Society


September 2021

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“Automatic Generation of SystemVerilog Models from Analog/Mixed-Signal Circuits: a Pipelined ADC Example” – Prof. Jaeha Kim, Seoul National University (SNU)

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